I'm only racist against 8-komas, real 4-komas are fine. The reason is 8-komas are really hard to read, not the 4-komas ones. But most people are not picky enough against their N-komas racism.
Also, anime adaptations from both 4- and 8-komas are generally way better.
I hate them purely because of me generalizing them and my experiences with most of them, not for any rational reason (though theres that but Im not picky abt it)