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That's a tough question because the answer keeps changing over time.

For me, the romance must be at the core of the plot. I don't want any gimmicks or overly complicated subplots. That's why I prefer slice-of-life stories.

Right now, I'm hooked on Lily Love 2 (I'm rereading it). It's a great romance with smut.

I also hold My Dearest Nemesis dear to my heart. It's a great romance with nice development.

Notable mentions:
The Moon on a Rainy Night (a great slow burn; it's a shame the scanlation group dropped it).

Asumi-chan is Interested in Lesbian Brothels! (Sex, sex, sex!)

Lilies Complex (smut with a plot).

Hana & Hina After School (slice of life).

I Can't Believe I Slept With You!

Kase-san Series

How Do We Relationship? (considered a masterpiece).

However, this answer could change completely in one month's time!