Poor Pandora... she's clearly gay and has no interest in having heterosexual sex with monsters. But she's so in love with her senapi that she's going along with it. That's honestly really sad. I feel bad for her.
As far as I know, an increase of any hostile monster population is not a good thing at all, not to mention them having genetic upgrades. This girl might eventually cause the end the humanity.
This manga should work like Dwarf Fortress, once it ends the "sequel" should swap perspective to an rpg about adventurers "cleaning up her mess" fighting all the upgraded monsters, confused where they come from, believing there's some sort of malevolent demon God at work. (For those unaware switching to adventure mode leaves your original fortress in the same spot as a lost civilisation sort of deal, nifty)
Such is a prime example of the selfishness of mages, thinking of none but themselves, and uncaring to the suffering it may bring to oth- mmmfffgghh seggss