@Yamibi eh could be her life force getting siphoned away but seems to be easier to be treated that way. Curse that affects her psychology and make her distrustful of people that are just trying to be kind to her feels like much harder to be cured.
Hmm probably a curse that affect how people see her. People keep saying how pale, colorless her face is everyday until she eventually accept it as truth, affecting her condition.
@flavorful It's a seinen series. I don't know what more they expect. If they only want lovey dovey development sweetness but hate slow character growth, there's a whole genre for that.