Shinohara Chie's Anatolia Story / Red River was one of the first isekai I ever read and it still stands heads and shoulders above it's contemporaries and more modern takes. Yuri is the poster child for adapting to her circumstances and thrives in a way she never would in modern-day Japan. I read this back when it was first scanlated, around 2007/2008 and I think I've reread it every year since then. It sparked my interest in archaeology (something I do for a living now) and taught me to expect better from historical fiction. All characters are balanced well and have well thought-out backstories and motivations. I feel for the side characters and villains as I do for our main heroine and the main love interest. Everyone feels like their live and breath this universe, that lives carry on without the reader there - a testament to her fantastic world building, attention to detail, and direction. Comics take a lot of planning and you can see Shinohara thought about every frame and aesthetic she could when parsing out her chapters.
If you haven't read this, or Shinohara's other works, you are doing yourself a disservice.