F***ing Hell, I wholly expected the two main human protagonists to get grievously bodily harmed in this series, but I didn't expect it to be this soon; figured it be a volume or two until we got to that point.
I wager a guess that Ryouma and Oryou are going to show up in 4.3 to drive off Izou and have Oryou reattach and heal Tsukumo's fingers. If that happens it going to make for a hot as hell scene.