Wait, is the Leo and Lisa here refer to "Leonardo da Vinci" and "Mona Lisa"? The look of Mona is pretty similar to the one In painting and Leonardo does live around that time but the young Leo looks a bit girlish that I thought it was a girl for a moment.
Or maybe the author just use the name because that is one of the most iconic thing from the 14s century Italy, so they name it like how Araki name stand after a song.