In isekai series, the MCs always get sent to a universe where their talents/personality are exactly perfect for survival for some reason. What I want is a series of 4-koma in which we get the different MCs sent to each other's worlds, and they fail miserably (and comically). So the girl from Simply Good Taste for a Duke's Daughter who survives by knowing economics and the ending of a game would go to, say, the world from Re:Monster and get eaten by a bunny. The guy from Re:Monster would go to the one where the crook becomes a summoner and has to reach the bottom of a dungeon, and is smacked down by a goblin. The kids from the series where they build a nuclear reactor would go to some futuristic world where nuclear reactor construction is a topic for first-graders and they're all hopelessly backwards compared to the geniuses. And so on.