That twist I didn't expect.
Her inner monologue when Mikane was talking with the doctor was so strong that he was able to see it XD.
I don't think she has any blame for her feelings or actions, quite the contrary actually... having been literally born from hatred it is impressive that she tried her best to do good for others, and the guy gave his flesh to her in the end, an entirely voluntary act.
This series really nails the subtle balance between melancholy and happiness, it is a trick one to achieve even once and this story is entirely supported by it.