One Piece - Digital Colored Comics - Vol. 31 Ch. 287 - Deicide

[MangaDex]

 

[GucciFlipFlops]

They had vaccinations from 400 years ago??? In the Pirate Era????? What year does one piece take place in

 

[Javelle2]

@gucciflipflops its somehere around age 1500s, but in one piece each island in the grand line has different levels of technological advancements due to their unique climates and magnetic fields, some islands are 1000s of years ahead while others are millions of years behind