Flirting. "Stop joking around"
Dating. "Seriously, you're taking it too far"
Proposal. "Oh, ha ha. Very funny"
Married with kids. "When are you going to let this joke go?"
Deathbed. "Wait, you were serious?"
nah, the drug mahiro takes is only M->F (or F enhancer). There's a separate drug Mihari made that was intended to suppress some of that drug's effects temporarily, but it also happened to work as a "low-yield" F->M drug if taken by a girl.