modern weapons blowing them up spread the spores ok.... so why not carpet bomb with incendiary bombs/ napalm afterwards to burn away the spores? send in shock troops with NBC gear and tanks to destroy them and quickly evacuate then quickly carpet bomb the area burning away any potential spores floating around
ok lets say the spores are heat/ fire resistant ... then carpet bomb with aerosol bombs and flatten it, I doubt even tough spores would survive that amount of pressure
ok lets talk small scale... flame throwers... its been a thing since ww1 turns out its pretty good at killing things too