It's definitely interesting to think about -- sure, there's the difference in Youko's skill compared to others' -- but it's also about how everyone's behaviour changes for her. Like they said earlier, she's being treated like a woman.
It's not her fault, but people are going out of their way and imprinting their own beliefs onto her -- that she shouldn't kill, that it's too dangerous for her, etc.
In some cases they're right, in other cases it might've been more advantageous to use her skills to give them the edge. Guess we'll see how it turns out.