did you notice that Umeko's interest in Matesuki started when he helped Take? I'm shipping the Umeko x Take platonic friendship. Though so far we've literally only been told they are friends (though it's implied she has been helping manage his chronic condition for years) and haven't seen much of it so it's not my actual prediction of how this turns out lol. And boy-girl platonic friendships are never a good bet in manga.