I mean, besides the top tier fighters, the Mink tribe unleashing a simultaneous Sulong form on Kaido's forces should cause massive amounts of damage to his side. At the very least, it should level the playing field a bit.
But, really, Luffy's side has a lot of very strong people this time around, but it goes to show how monsterous Big Mom and Kaido are as individuals.
I don't see Kaido or Big Mom being defeated for good without an additional surprise powerhouse appearance, but I do see them losing and fleeing. Afterward, I imagine they'll truly combine their power -- perhaps even under someone else.