Well Yoishi is willingly ignoring both the age discrepancy with Ukano and that Almurack is constantly referring to her as sama
I mean she has a tail and horns, he KNOWS she's not a regular human, and considering how casually he responds to a vampire, i just don't think he cares all that much, like sure she might be older then him, but she IS still a kid, just one that ages much slower then he does cause she's a different species and whatnot.
Though it's a bit sad, considering how similar she looked in that flashback to 50 years ago, she'll probably still be a child when he dies, thats not inherently sad, kids are supposed to outlive their parents, but their also supposed to be adults by the time they die, she's still gonna be a kid, i hope someone else can take care of her when he's gone.
Or maybe he'll reject his humanity and become a vampire lol.