Hormones don't change your sexual orientation. Unless Nicole's body is a heteresexual, then I guess you can say that hormones could push her to get attracted to guys. Otherwise if she has a homosexual body (like I suspect), all the hormones will do is make her doki doki for girls.
But I doubt that we are going to get an actual explanation of her developing sexuality. And I'm pretty sure if she is going to get hooked up it will be with the archer-chan.