The difference between someone who genuinely wants to help people and someone who just wants to prove themselves right.
There is no guarantee that working hard will make your wish come true, but giving up on something simply because it is difficulty to achieve won't make you grow as a person. The lessons you learn with failure build character and that knowledge paves the path to something concrete for yourself and others.
Neko may not have what it takes to refute that bitch witch now, but she is on the right path. Meanwhile, Kurosaki is just giving up on everything and patting herself on the back, and if that wasn't enough she's also dragging others down with her on this path of self destruction.