I don't have a heavy preference, it depends entirely on the author's storytelling through visuals. Like, some genres work better than others in the long strip. I've found that action sequences in particular are difficult to pull off vertically, though some manage. However I do find it easier to read digitally when it's in long strip. Like, some manga have those long panels where you have to scroll down to read something and then scroll back up to read the next panel. Would be perfectly fine reading that as a physical book, but doesn't work as well as a digital medium. Thats kinda what I see the long strip format being particularly useful for in the modern world, now that physical paper books are becoming obsolete, and they're extremely easy to navigate on small mobile platforms especially which seems to be what everyone uses anymore for all their online needs. (Me though, I'll be dead in the cold hard ground before my phone fully replaces my laptop. I want my big screen.)
Now what I have a real opinion on is the monsters that upload an opened up 2 page spreads as one page, requiring me to bounce up and down the whole way through to read the damn thing lol.
