This is a masterpiece. They took the tsundere trope, made it a clinical, hereditary disease, and have fleshed out a serious story that explores everything from the way people treat each other normally, how some use crippling diseases as an excuse, and it excellently explores how the "cripple" herself would grow up and mature while dealing with everything at once.
This isnt lighthearted, tropey manga. Its here to make you reconsider your perspectives, to show you that there are more than just one or two perspectives to every situation, countless opinions and complications arising from any interaction, and far too many misconceptions and misunderstandings we experience on a daily basis.
The part with the stock market is a great allegorization of the entire story: she's good at reading everything around her, but in the end discovers that there are far more factors in play she cant understand or control. Its the same thing with every one of her relationships, and with life in general. Nobody is perfect, nobody knows everything. Everybody is struggling to make sense of things, to deal with their own situations and feelings, and if you step back and look at it all from a wider angle you can see that it's all just a huge mess.
The tsundere disease is obviously fictional - but what we're being shown here applies to every other form of being somehow crippled, to every kid diagnosed with some "problem", as well as " normal" people who aren't actually all that much different from the "weirdos".
This manga is one of those once in a lifetime masterpieces that can open your eyes to a lot of things. Like when they made kids read " The Child Called It" in school to get kids and teachers to open their eyes to bullying and abuse and how we treat each other, though I would say this is a far more potent story that covers a lot more than shoving a single stereotype situation into your face.