This was interesting, but really dark. Like, depression, attempted suicide, self injury, intense gaslighting, garbage parents, and a whole bunch of other mental health stuff. The story is empathetic about it, and has a happy ending, but if you're someone who struggles with really intense subjects you may not wanna read it. Also the author sometimes frames the mental health stuff in a new-age kind of way. That's the "evolution" stuff that other commenters are talking about. I dunno if it made sense in 1998 when it was written, but by modern standards it is quite strange. However, its a very minor aspect to an otherwise medically realistic story, and doesn't hurt the overall manga.