Oh... there are many.
On the front of taking the Inquisition headfront... I think it isn't possible, he left it to grow too much and out of his control, maybe his predecessors didn't do much either, but he still is to feel how much that will bite them in the ass.
But if they do it the smart way... he still sponsored the Inquisition, which means he still has money, so if they play their cards right they can do something about it and not let the Inquisition turn on them, but that will demand finesse.