@Random_Passer-by
Too add to this, took a while to compile from what im reading, heres a list of Female Lead Isekais.
https://mangadex.org/title/20978/the-world-of-moral-reversal
https://mangadex.org/title/24244/kuma-kuma-kuma-bear
https://mangadex.org/title/17720/koushaku-reijou-no-tashinami
https://mangadex.org/title/27433/isekai-omotenashi-gohan
https://mangadex.org/title/17709/kumo-desu-ga-nani-ka
https://mangadex.org/title/24988/gyaru-tensei-isekai-seikatsu-majidarui
https://mangadex.org/title/23013/the-vengeful-white-cat-lounging-on-the-dragon-king-s-lap
https://mangadex.org/title/23716/wanwan-monogatari-kanemochi-no-inu-n-shite-to-wa-itta-ga-fenrir-ni-shiro-to-wa-itte-nee
https://mangadex.org/title/22369/jahy-sama-wa-kujikenai
https://mangadex.org/title/18488/honzuki-no-gekokujou
https://mangadex.org/title/20338/tensei-shitara-ken-deshita
https://mangadex.org/title/22843/saving-80-000-gold-coins-in-the-different-world-for-my-old-age
https://mangadex.org/title/18803/youjo-senki
Theres a strong argument to be made that Aura is could be considered a Protagonist in this
https://mangadex.org/title/20719/risou-no-himo-seikatsu
This one focuses on the girl more than anyone so it should count as female led.
https://mangadex.org/title/19472/if-it-s-for-my-daughter-i-d-even-defeat-a-demon-lord
This one the MC is the goblin girl, but her cast is full of Isekaid Japanese kids.
https://mangadex.org/title/21177/goblin-is-very-strong
this one is Tensei, but its fantasy so
https://mangadex.org/title/23467/eiyuu-no-musume-toshite-umarekawatta-eiyuu-wa-futatabi-eiyuu-o-mezasu
This one is straight up fantasy
https://mangadex.org/title/22863/kenshi-wo-mezashite-nyuugaku-shita-no-ni-mahou-tekisei-9999-nan-desu-kedo