What a disappointment, though Yotsuba is the childhood friend and energetic girl that usually gets friendzoned in anime,manga and vns, Yotsuba was the least interesting of the quintuplets, if you take out the childhood memories there's basically nothing of her. Moreover out of the quintuplets she has no goal in her life and was the one who never grew up and until the end she kept accepting other people request without any regards for herself and those who care for her. Not to mention she's the one with the worst marks on her report cards. I guess the author will use these shortcomings to "fix her" and squeeze some more chapters out the manga.
Honestly I would have been fine with any of the other girls, or even Uesugi rejecting them now and actually getting close to one of them later after graduating from college