@ceneoss: If this follows the story of the original (this is a remake of an old Tezuka manga, which is why he’s listed as co-author despite being dead for decades) then no, Hyakkimaru has massive psychic powers which substitute for his senses, and convincing-looking prosthetics. (He can’t use them to fight, for some reason, but they let him move his artificial limbs and have Daredevil-style sensory accuracy.) His missing parts grow back and push the prosthetics out of his body when he kills demons.
In general, I hope this ends up being better than the original — the Tezuka version starts when Hyakkimaru has killed a few demons, I forget how many but not a lot, gives his background story in great detail, has him meet Dororo (who has a whole other plot going on), follows him through encountering his biological family, they figure out Dororo’s big plot point (which I am not spoiling here, go read the original if you want to know), and then Hyakkimaru just walks off leaving Dororo alone, and there’s like 2 pages saying that Dororo learned from rumors that he eventually managed to kill all the demons.
(Incidentally: they made a game based on the manga for the Playstation 2 called
Blood Will Tell, but since Hyakkimaru is the MC in the game and it follows him through killing
all the demons, the plot can’t be quite the same as the original, so don’t assume you know what’s going to happen if you’ve played it.)