Yeah, now i'm sure of it, Elisa will not finish this story alive, that's why she reject him so hard, she know she don't have long to live after injecting herself tons ot drugs for the tests.
Or we will get a more boring option, where she just say something boring to Raito like "I'm not the one you like the most anymore, right ?", but i really hope it will not be that, it's so cliché.