Every chapter is a little masterpiece. Azuma manages to capture the life of a child so wonderfully.
Notice just how in the latest chapter (100) on page 4 at the bottom, Yotsuba is going slowly to not spill anything while Yousuke is already out of frame in the last panel. It might not seem like much but it‘s such details (children don‘t have perfect motor skills yet) that many manga with children don’t show and what makes Yotsuba to! truly special.