The art leaves a lot to be desired, but it's also pretty damn hilarious how she was a serious no-nonsense honor student that is suddenly dealing with the desires and preferences of a horny teenage boy and doing so unconsciously. That last couple of pages with her staring with that goofy grin was funny.
And the people mentioning the brain transplant thing do have a point. Injuries and trauma to the brain can cause a bunch of different psychological issues and changes. That guy "Phineas Gage" who was famous for having the railroad spike lodged in his brain and surviving did survive, but his personality and mannerisms were completely changed. Eh, whatever. It's funny and it's gay girls doing gay things, I ain't gonna complain.