I'm certain Wonder of U is a reference to the Final Destination movies. In the movies a "knocking effect" causes a Rube Goldberg chain of events every time it's activated to hurt the target, with increasingly absurd scenarios and chains of events. But a big part of the movies was the curse itself being fueled by a massive calamity being avoided, by the main protagonist seeing the future and avoiding it. Which doesn't exist here. More importantly, it is something that was exclusively seen in the original universe.
I have so many questions, and I want answers so badly. This is like the only series that makes me scratch my head like this and I fucking love it.