There's one little trick with PNGs that the savvy scanlators use to very good results and one that completely blows JPG out of the water in a fair comparison.
High-quality scans, especially when done on a high-detail manga with lots of shading and complex gradients, will always be very grainy: both because of the ubiquitous pattern fill and because the high resolution exposes printed ink granularity. This, by itself, is absolutely horrible for compression as PNG performs best on solid colors, and noisy/grainy images inevitably bloat its filesize. But it also works to your advantage if you know how to deal with it the best way, which is
reducing the colors further and using dithering to compensate for gradient fidelity, which is something JPG cannot do. Since the image is already grainy due to the natural dithering of ink printing, it successfully masks any dithering artifacts that would have become more obvious on a manga with solid colors.
To give you an example just how well it actually works, let's take
this beautiful two-page spread from Kokou no Hito. It is actually a JPG image, and is already pretty heavily compressed, but that doesn't matter too much as in this case it's basically impossible to tell with a naked eye where the artifacts are among all the visual noise (in fact, let's take that as a challenge to see how far we can push PNG is in this context).
Here's an Imgur album with all images fully optimized (including the original JPG), including diff comparisons. I used Photoshop CS6 to make PNGs and File Optimizer to crunch them out (notably, the best it managed to produce was 9% reduction on the most color-starved versions with 5–6% on average across the set—Photoshop is actually very good at this already). Filesizes are included in descriptions, and you can download the album and run your own diffs. Outtakes: at 32 colors PNG is
completely indistinguishable from the JPG, at 24 colors dithered it almost catches up and would have overtaken the JPG by
both size and quality if we had access to the original image, and at 16 colors dithered it
still manages to compete in quality while having a comfortably lower filesize.
Here's another example with
Vagabond: this time we have the original PNG so we can compare apples to apples. Results: 256 colors → 16 colors dithered, 991 KB → 600 KB flat.
Can you spot the difference? Mind blown yet?
This is the reason why e.g. all Berserk volumes released by Evil-Genius have at most 64 colors (and even then it's just contingency, you wouldn't have noticed it if they halved it). They just don't need any more. This will also be the case for any high-detail artwork.