I'll try to analyze this from an "objective" standpoint disregarding the social politics of this work. At times, it's pretty hard to tell who's talking about who, especially at the beginning. And for most of the story, it's less about the relationship between the two of them or even actually about exploring their identities so mich as just... throwing the concepts out there in hopes that it makes things interesting. For a few pages, it becomes an interesting story about a trans girl... except, they then make the character bigender so it kind of weasels its way out of that by making him comfortable with being a boy as well. At the end, when the two are embracing, it gets kinda cute and the "I really feel like a boy" line makes it almost matter that the character is bigender, but... I dunno, man. Kinda feels like they made it a (physically) het pairing and used the term otokonoko in the title specifically to make the whole thing more palatable to the japanese audience.
The side character who was in love with the bigender boy exists purely to be demonized even though she's basically just having a bad reaction to her worldview being challenged. It's hard for me to see her in as bad a light as the story clearly does, and from an audience perspective, she really should be the perspective character. She has an interesting conflict--a girl who has a rigid understanding of gender, yet falla in love with a crossdressing/bigender boy. She has a deep character flaw in that she can't hold back speaking poorly of people, which could be interesting to watch her work through as she comes to accept a new perspective on gender. Her rejection could serve as a turning point, and even if she ends up never getting her love requited, she'd come away from it a changed and better person.
Overall analysis: tone down the borderline-propagandistic elements and cut the page length to about half or maybe 2/3 of the current length and it could be improved, with the lower pagecount forcing the author to pace it differently and trim the fat. Either that, or make a longer story with that other girl as the protagonist. The art is appealing, so it definitely has that going for it. I'll definitely be watching this artist to see what they come up with next, even though I thought this one wasn't good. There's a lot of unrealized potential here.