It's also not exactly "globalization ends autonomy" but rather "globalized capitalism leads to global oppression", or thereabouts, I think.
"it's never been done before" is a poor argument to suggest it can't or shouldn't be done, however.
True because its leading to a world power but keeping the political divisions as well keeping the power of the state weakened, we seen with Mastercard recently because the state lost control over payment services.
As for unification within a single nations, eventually we will get there but even with current technology it would be very hard ... the problem is that is a resistance due to natural interests to get there, look at the EU for example ... it "works" but have deep issues such as a common defense policy or even the US that today have deep divisions because even if there is a strong common sense of national identity, when it comes to details things arent as clear cut anymore.
Also I dont think he Emperor is right because the issue is ... he is mortal and no matter how good and capable ruler he is, it will eventually break apart, a unification needs to come from a strong desire like what happened in Italy and Germany or from a system that gets too complex and useful to be torn down, the the EU.
Its kinda funny as I do see and actually agree with his point since naturally humanity will drive into a unified front as Kai "self-determination" is naive and self-defeating ... but the system needs to be robust to survive and that requires the people to accept it, not something forced unto then.