You guys talking about Foolysexual don't make sense to me.
If this was the other way around and Leo turned into a guy, Fooly'd be sad and would want her to turn back into a woman. If it was permanent then Leo(M) and Fooly would probably become friends. The difference here is that when Fooly turned into a girl Leo started showing physical attraction towards him instead of her usual emotional attraction.
She was even disappointed when he turned back.
Obviously, this is a joke on the writer's part, but it's still gonna reencode their previous interactions. Leo's more Bi, female leaning in physical attraction. If she's stringing him along and there's really only an emotional attraction I think it makes sense that they just become friends in the end.
Personally, I don't like this development, and it's really killed my interest in the series.