Ahhhhh... That really hits you right in the chest... One part of me is sad, because we've seen these two people grow closer over the months, but a small part of me is now getting extremely excited about Iino's arc (although a lot of time will have to pass until Ishigami gets over his feelings and for him to even consider Iino), which will, undoubtedly, be amazing. Aka never dissapoints.
Edit: why tf are poeple mad about getting Iino route? It was setup this way long ago. Also, the guy doesn't always have to end up with the girl he asks out. This is realistic.