Hey there, translator. Thank you for your continuing efforts. And since you asked...
Always
Always
ALWAYS
use the Japanese honorifics. The Englsh "equivalents" are not at all equivalent in both flow and context. As I'm sure you know, there are at least a dozen ways to refer to one's elder sibling, and they are all laden with individual meaning and status. Calling someone "Big Sis" or "Big Bro" communicates none of this information and sounds completely janky to any native English speaker's ear, no matter which part of the world they speak English in.
99.9% of you audience here fluently understands honorifics and other indicators of social status, family terms, and many culinary terms as well. If Kaa-san and Onee-chan say “Itadakimasu” before eating okonomiyaki at an onsen in Hokkaido during Golden Week, you don't have to try to explain any of that. For things like that, romaji is translation enough. If you are still in doubt, just gloss it in the margins, just in case some newbies are actually picking your translation as their First Manga Evar.
The average manga reader reads a lot of manga, so Japanese terms are as invisible as water is to a fish. Needless attempts at pointless English localization however are jarring and push the reader out of the flow of what they are reading. Never change Yuuki -san to Mr. Yuuki or Alice-sama to Dame Alice or Tomo-aneki to Big Sis Tomo. It's inaccurate, and it actually hides information.