Eh, I've seen bigger be done perfectly fine, it's just that the proportions here are all off. The shoulders are way too broad, and Neiro's jawline has completely changed shape for no reason. Obviously, the author made Neiro look extra mannish because that's the joke, but if the author were interested in doing "buff Neiro" as more than just a one-page gag, I'd suggest something more like this piece by
SheepApp:
This girl's arms are actually about the same size as page 14 Neiro's relative to the size of their heads (obviously we're speaking proportionally here), but the shoulders are kept a lot more narrow, keeping the body shape a lot more feminine despite the buffness. It's a good example of how an artist could put a lot of muscle on a body type like Neiro's without making her look like a totally different person.