The thing why I find Demi-chan more enjoyable is despite going scientific on how monstergirls work(honestly there is a LOT of series that does that, Kakeru did an amazing fictional encyclopedia for that) there is still the very clear wall of fiction separating it from reality, which is monstergirl's existence.
With this series the only wall of fiction it has is the disease that magically genderbends you. But everything around that is just trying to mash real world stuff to work with the fictional disease... Like I would honestly enjoy this series more if the magic disease isn't a thing...